Metformin and the eye

Shahsuvaryan, M.L. (2026) Metformin as an Emerging Candidate for Diabetic Retinopathy, Age-Related Macular Degeneration and Glaucoma Pharmacotherapy: Evidence and Perspectives. Current Reviews in Clinical and Experimental Pharmacology. https://doi.org/10.2174/0127724328519947260917114932 This article caught my eye because I started taking metformin a few months ago. My a1c has been stubbornly at 5.8 for years, and my doctor and I decided it was time to do something. I was shocked at how cheap it was. I have a decent high deductible plan, and it was only $3 for a 90-day supply. Crazy. Obviously, metformin reduced the incidence of DMR because it lowers blood sugar. However, it has been shown to have antioxidant, antioxidant, anti-inflammatory, autophagy-promoting, antiangiogenic, antifibrotic, and neuroprotective properties. Also, it can cross the blood-retinal barrier. This paper is a review of studies that show the degrees that metformin can reduce the morbidity from not only diabetic…