State of Pandemic Early Warning

Cross-posted from my SecureBio Notebook. This is a lightly-edited version of a memo that I presented at the Summer 2026 Biosecurity Summit outside of DC. While others at SecureBio often see things similarly, I'm attempting to present my view and not a SecureBio "house view". The Goal We need to be robust to adversaries who want to cause very large-scale harm with biology. This includes actors (human or AI) who want to kill all humans, cause short-term incapacitation or long-term civilizational collapse, or who have strategies for sparing some while they harm others. There are multiple reasons an actor might have these targets aside from being directly omnicidal, such as reducing response capacity during an AI takeover. That there is an attacker itself is a key constraint to any defensive system: it must be designed for adversarial attacks. The attacker can assess the state of the world's detection systems and plan accordingly. Taken to the extreme, this presents a "minimax" landscape:…

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