Fenofibrate and the eye

Ho SC-H, Lee IXY, Liu C, Yu M, Tan HC, Tan GSW and Liu Y-C (2026) Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms. J. Pharm. Pharm. Sci. 29:16995. doi: 10.3389/jpps.2026.16995 I have genetically high triglycerides, and I have taken fenofibrate in the past. I think that’s what drew me to this article. There is some evidence that fenofibrate can have benefits in diabetic corneal neuropathy, dry eye, corneal injury, Fuchs dystrophy, diabetic retinopathy, and AMD. Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It is found in tissues that are very highly metabolically active, such as liver, heart, skeletal muscle, kidney, brown adipose tissue, vascular wall cells, retina, and cornea. In addition to increasing fatty acid oxidation and ketogenesis, PPARα has significant anti-inflammatory, antioxidant, anti-angiogenic, neuroprotective, anti-fibrotic, and barrier-stabilizing effects. This is a very dense, in-depth article, but I will…