2 hours ago · Writing · 0 comments

(Yes, but.) Over the past few years, I’ve seen many articles about mysterious rise in colorectal cancer (CRC) in young people. There are various stories for why this might be happening: General health. Maybe modern people are unhealthy (obesity, low physical activity, diabetes, poor sleep), leading to insulin resistance and chronic inflammation, meaning faster epithelial cell proliferation and a miscalibrated immune system that fails to stop early cancers? Ultra-processed food. Maybe people are eating more ultra-processed foods that contain additives (like emulsifiers) that degrade colon mucus, allowing bacteria to contact epithelial cells and drive inflammation? Or maybe ultra-processed food has low fiber and glycemic load, leading to insulin resistance and chronic inflammation, with the problems mentioned above? Bad meat. Maybe people are eating more red and/or processed meats, which expose the colon to nitrites and secondary bile acids, which inflame the epithelium and promote…

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