When Diabetes and Depression Overlap: What Inflammatory Markers Reveal

Association between inflammatory biomarkers and depressive symptoms among diabetes mellitus and diabetic retinopathy: A cross-sectional study Tang S, Li H, Wang Z, Wang B, Li Y, Dai C. Association between inflammatory biomarkers and depressive symptoms among diabetes mellitus and diabetic retinopathy: A cross-sectional study. Medicine. 2026;105(20):e48915. doi:10.1097/MD.0000000000048915 Depression is a well-documented complication of diabetes, occurring at three to four times the rate seen in the general population. Add to that the fear of developing vision loss from diabetic retinopathy or the stress from already having vision loss, and the psychological burden is even worse. Is there a metabolic cause to this? This study looked at four inflammatory biomarkers and their relationship to people with diabetes: neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), aggregate index of systemic inflammation (AISI), and systemic immune inflammation index (SII).…